Gene | Polymorphism | Reference Allele | Severe CAP | Respiratory failure | CURB-65 | PSI | Time to clinical stability | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (CI 95%) | p | OR (95% CI) | p | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | |||
IL10 | rs3024498 | G | 1.05 (0.49–2.25) | 0.91 | 0.8 (0.41–1.53) | 0.5 | 0.02 (0.15) | 0.91 | −0.11 (0.16) | 0.51 | 0.26 (0.45) | 0.57 |
IL10 | rs3024509 | C | 0.17 (0.02–1.39) | 0.10 | 0.18 (0.-0.57) | 0.003 | −.4 (0.19) | 0.04 | −.54 (0.21) | 0.01 | −1 (0.58) | 0.09 |
IL12B | rs730691 | T | 0.55 (0.27–1.12) | 0.10 | 0.8 (0.46–1.4) | 0.43 | −.23 (0.13) | 0.07 | −.28 (0,13) | 0.04 | −.21 (0.38) | 0.59 |
IL4 | rs2227284 | A | 2.17 (1.02–4.61) | 0.04 | 0.96 (0.52–1.76) | 0.89 | −.01 (0.14) | 0.92 | −.07 (0.15) | 0.65 | −0.02 (0.43) | 0.97 |
ILR1 | rs13020778 | C | 0.84 (0.42–1.67) | 0.62 | 0.64 (0.36–1.14) | 0.13 | 0.06 (0.13) | 0.65 | 0.01 (0.14) | 0.94 | −0.83 (0.37) | 0.03 |
ILR1 | rs2160227 | A | 0.99 (0.48–2.05) | 0.97 | 0.72 (0.38–1.34) | 0.30 | 0.01 (0.14) | 0.93 | <.01 (0.15) | 1 | −1.00 (0.42) | 0.02 |
ILR1 | rs3917254 | A | 0.62 (0.22–1.79) | 0.38 | 0.91 (0.41–2.03) | 0.82 | −.16 (0.19) | 0.40 | −.33 (0.2) | 0.09 | −0.13 (0.55) | 0.81 |
ILR1 | rs3917267 | A | 1.86 (0.9–3.82) | 0.09 | 3.33 (1.62–6.86) | 0.001* | 0.18 (0.13) | 0.19 | 0.09 (0.14) | 0.55 | 1.07(0.4) | 0.008 |
NFKBIA | rs1050851 | A | 1.85 (0.9–3.79) | 0.09 | 1.14 (0.58–2.23) | 0.71 | 0.11 (0.14) | 0.45 | −.10 (0.16) | 0.52 | −0.19 (0.43) | 0.67 |
NFKBIA | rs696 | A | 0.88 (0.44–1.78) | 0.73 | 1.55 (0.86–2.8) | 0.14 | −0.02 (0.13) | 0.88 | 0.15 (0.14) | 0.28 | 0.18 (0.4) | 0.65 |
NFKBIE | rs2282151 | C | 0.57 (0.24–1.36) | 0.21 | 0.89 (0.47–1.8) | 0.71 | −.12 (0.15) | 0.41 | −.12 (0.16) | 0.44 | 0.38 (0.44) | 0.39 |
NFKBIE | rs730775 | G | 0.79 (0.41–1.53) | 0.49 | 0.75 (0.43–1.29) | 0.29 | .03 (0.13) | 0.84 | 0 (0.14) | 0.99 | −0.89 (0.37) | 0.02 |
NFKBIZ | rs11718446 | A | 1.64 (o.74–3.62) | 0.22 | 0.75 (0.38–1.49) | 0.41 | 0.07 (0.15) | 0.64 | −.11 (0.17) | 0.51 | 0.08 (0.46) | 0.87 |
NKFBIZ | rs645781 | C | 0.59 (0.26–1.31) | 0.19 | 0.77 (0.43–1.41) | 0.40 | −.05 (0.14) | 0.74 | −.01 (0.15) | 0.94 | −0.61 (0.41) | 0.14 |
NFKBIZ | rs677011 | G | 0.79 (0.39–1.6) | 0.52 | 0.82 (0.47–1.43) | 0.48 | −.11 (0.13) | 0.39 | 0.02 (0.14) | 0.89 | −0.75 (0.39) | 0.06 |
NFKBIZ | rs9841857 | T | 1.12 (0.52–2.39) | 0.78 | 1.24 (0.66–2.34) | 0.51 | 0.19 (0.15) | 0.19 | 0.10 (0.16) | 0.54 | −0.11 (0.44) | 0.8 |