Table 1 Description of the 4 Australian paediatric non-typeable Haemophilus influenzae (NTHi)-carriage cohorts used in this study
Study | Study design, setting and participant ethnicity | Year of data | No. enrolled children (NTHi carriage rate) | Child eligibility age & other key criteriab | Collection frequency (No. NTHi positive swabs) | No. unique NTHi typeda (Total NTHi typed) | No. PRTs (No. per 100 swabs) |
|---|---|---|---|---|---|---|---|
1 | Cluster RCT of a hygiene intervention in 20 Darwin (NT) child care centres. 90 % were non-Aboriginal [10] | 2001 | 456 (50 %) | 0–4 yrs, attending 3 d/wk | Fortnightly for 6 m (2,012) | 2,179 (2,201) | 84 (4) |
2 | RCT of azithromycin vs amoxicillin for AOM in 16 remote NT communities. All were Aboriginal children [11] | 2003–2005 | 320 (316 with swab data) (85 %) | 0.5–6 yrs with AOM | Days 0 and 6–11. Additionally, Day 12–21 if perforation. (469) | 551 (569) | 73 (13) |
3 | Kalgoorlie (WA) Otitis Media Research Project. Prospective Aboriginal cohort [12, 14] | 1999–2005 | 100 (36.3 %) | 1 wk to 24 m | Ages 1–3, 6–8 wks, then months 4, 6, 12, 18, 24. (193) | 231 (346) | 65 (28) |
4 | Kalgoorlie (WA) Otitis Media Research Project. Prospective non-Aboriginal cohort [12, 14] | 1999–2005 | 180 (9.4 %) | 1 wk to 24 m | Ages 1–3, 6–8 wks, then months 4, 6, 12, 18, 24. (102) | 109 (192) | 37 (34) |