Drug-resistant tuberculosis and advances in the treatment of childhood tuberculosis

Pneumonia

Table 1 New drug groupings published by the World Health Organization in 2016 [75]

	Drug group		Drug name	Abbreviation	Important Adverse Events
A	Fluoroquinolones		Levofloxacin	Lfx	Sleep disturbance, GI disturbance, arthritis, peripheral neuropathy,
			Moxifloxacin	Mfx	As levofloxacin with QTc prolongation
			Gatifloxacin	Gfx	As levofloxacin with QTc prolongation
B	Second-line injectable agents		Amikacin	Am	Ototoxicity, nephrotoxicity
			Kanamycin	Km	As amikacin
			Capreomycin	Cm	As amikacin
C	Other core second-line agents		Ethionamide/Prothionamide	Eto/Pto	Gastrointestinal disturbance, metallic taste, hypothyroidism
			Cycloserine/Terizidone	Cs/Trd	Neurological and psychological effects
			Linezolid	Lzd	Diarrhoea, headache, nausea, myelosuppression, neurotoxicity, optic neuritis, lactic acidosis and pancreatitis
			Clofazimine	Cfz	Skin discoloration, abdominal pain, QTc prolongation
D	Add-on agents	D1	Pyrazinamide	Z	Arthritis/arthralgia, hepatitis
			Ethambutol	E	Optic neuritis
			High-dose isoniazid	hH	Hepatitis, peripheral neuropathy
		D2	Bedaquiline	Bdq	Headache, nausea, liver dysfunction, QTc prolongation
		D2	Delamanid	Dlm	Nausea, vomiting, dizziness, paresthesia, anxiety, QTc prolongation
		D3	p-aminosalicylic acid	PAS	GI intolerance, hypothyroidism, hepatitis
			Imipenem-cilastatin	Ipm	GI intolerance, hypersensitivity reactions, seizures, liver and renal dysfunction
			Meropenem	Mpm	As Imipenem
			Amoxicillin-clavulanate	Amx-Clv	As Imipenem

ISSN: 2200-6133