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Table 1 New drug groupings published by the World Health Organization in 2016 [75]

From: Drug-resistant tuberculosis and advances in the treatment of childhood tuberculosis

  Drug group   Drug name Abbreviation Important Adverse Events
A Fluoroquinolones   Levofloxacin Lfx Sleep disturbance, GI disturbance, arthritis, peripheral neuropathy,
Moxifloxacin Mfx As levofloxacin with QTc prolongation
Gatifloxacin Gfx As levofloxacin with QTc prolongation
B Second-line injectable agents   Amikacin Am Ototoxicity, nephrotoxicity
Kanamycin Km As amikacin
Capreomycin Cm As amikacin
C Other core second-line agents   Ethionamide/Prothionamide Eto/Pto Gastrointestinal disturbance, metallic taste, hypothyroidism
Cycloserine/Terizidone Cs/Trd Neurological and psychological effects
Linezolid Lzd Diarrhoea, headache, nausea, myelosuppression, neurotoxicity, optic neuritis, lactic acidosis and pancreatitis
Clofazimine Cfz Skin discoloration, abdominal pain, QTc prolongation
D Add-on agents D1 Pyrazinamide Z Arthritis/arthralgia, hepatitis
Ethambutol E Optic neuritis
High-dose isoniazid hH Hepatitis, peripheral neuropathy
D2 Bedaquiline Bdq Headache, nausea, liver dysfunction, QTc prolongation
Delamanid Dlm Nausea, vomiting, dizziness, paresthesia, anxiety, QTc prolongation
D3 p-aminosalicylic acid PAS GI intolerance, hypothyroidism, hepatitis
Imipenem-cilastatin Ipm GI intolerance, hypersensitivity reactions, seizures, liver and renal dysfunction
Meropenem Mpm As Imipenem
Amoxicillin-clavulanate Amx-Clv As Imipenem