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Table 10 Change of antibiotic therapy after rtPCR, all patients with another indication for antibiotics were excluded

From: Impact of viral multiplex real-time PCR on management of respiratory tract infection: a retrospective cohort study

  Viral Bacterial Mixed No pathogen Clinically Clinically p-value c
(n = 62) (n = 37) (n = 9) (n = 102) bacterial a (n = 106) viral b (n = 28) Viral vs. bacterial Viral vs. mixed Viral vs. no pathogen
No antibiotic treatment before and after rtPCR, n (%) 22 (35.5) 8 (21.6) 2 (22.2) 38 (37.3) 24 (22.6) 19 (67.9) 0.15 0.71 0.82
Antibiotic treatment stopped after rtPCR, n (%) 8 (12.9) 2 (5.4) 0 (0.0) 3 (2.9) 6 (5.7) 4 (14.3) 0.40 0.64 0.03
Antibiotic treatment started after rtPCR, n (%) 6 (9.7) 4 (10.8) 3 (33.3) 11 (10.8) 10 (9.4) 3 (10.7) 1.00 0.16 0.82
Antibiotic treatment before and after rtPCR, n (%) 26 (41.9) 23 (62.2) 4 (44.4) 50 (49.0) 66 (62.3) 2 (7.1) 0.05 1.00 0.38
Correct management, n (%) 30 (48.4) 27 (73.0) 7 (77.7)   76 (71.7) 23 (82.1) 0.02 0.19 n/a
  1. n number; rtPCR, real-time polymerase chain reaction
  2. aCases without detection of bacteria were evaluated as clinically bacterial if they fulfilled one of the following criteria: unilobular or multilobular pulmonary infiltrate or CRP >100 mg/l or PCT >0.25 μg/l or antibiotic therapy before rtPCR and no bacterium detection and biomarkers indeterminate (CRP >100 mg/l and PCT ≤0.25 μg/l or CRP between 51 and 100 mg/l and PCT not available)
  3. bCases with a detected viral pathogen excluding those patients with a clinically bacterial co-infection (as described above)
  4. cMantel-Haenszel chi square test or Fisher exact test were used