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Table 5 Outcome depending on relevant detected pathogen for adult patients

From: Impact of viral multiplex real-time PCR on management of respiratory tract infection: a retrospective cohort study

  Viral Bacterial Mixed No pathogen p-value a
(n = 40) (n = 36) (n = 6) (n = 100) Viral vs. bacterial Viral vs. mixed Viral vs. no pathogen
LOS inpatients, median days (IQR) 8 (6–21) 21 (13–35) 11.5 (5–44.25) 15 (8–23.5) <0.001 0.67 0.03
 Complications, n (%)
  ICU admission 11 (27.5) 13 (36.1) 3 (50.0) 24 (24.0) 0.42 0.51 0.67
  Mechanical ventilation 6 (15.0) 11 (30.6) 3 (50.0) 19 (19.0) 0.11 0.16 0.58
  ARDS 3 (7.5) 5 (13.9) 2 (33.3) 6 (6.0) 0.60 0.24 1.00
  Sepsis 24 (60.0) 24 (66.7) 5 (83.3) 6 (6.0)b 0.55 0.53 n/a
  Mortality (all cause) 4 (10.0) 4 (11.1) 1 (16.7) 6 (6.0) 1.00 1.00 0.62
 Antibiotic use (any indication)
  Any inpatient antibiotics, n (%) 30/35 (85.7) 29/32 (90.6) 4/6 (66.7) 72/89 (80.9) 0.81 0.54 0.53
  Duration of inpatient use, mean days ± SD (range) 12.5 ± 14.3 (0–63) 18.1 ± 16.0 (0–72) 10.3 ± 12.1 (0–31) 10.8 ± 11.4 (0–63) 0.14 0.73 0.49
  Discharged receiving oral antibiotics, n (%) 11 (30.6)c 17 (53.1)d 1 (20.0)e 23 (24.5)f 0.06 1.00 0.48
  1. ARDS acute respiratory distress syndrome, ICU intensive care unit, IQR interquartile range, LOS length of stay, n number, SD standard deviation
  2. aFor continuous variables, 2-sample independent t-test or Mann-Whitney-U-test were used. For categorical variables, Mantel-Haenszel chi square or Fisher exact test were used
  3. bSepsis requires a pathogen per definition. In these six cases sepsis was exceptionally defined according to discharge papers
  4. Missing values due to death or ongoing hospitalisation at time of analysis (number): c4; d4; e1; f6. For calculation of percentage and p-value missing values were excluded