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Table 8 Change of antibiotic therapy after rtPCR, adult patients with another indication for antibiotics were excluded

From: Impact of viral multiplex real-time PCR on management of respiratory tract infection: a retrospective cohort study

 

Viral

Bacterial

Mixed

No pathogen

Clinically

Clinically

p-value c

(n = 35)

(n = 33)

(n = 6)

(n = 84)

bacterial a (n = 84)

viral b (n = 13)

Viral vs. bacterial

Viral vs. mixed

Viral vs. no pathogen

No antibiotic treatment before and after rtPCR, n (%)

10 (28.6)

7 (21.2)

2 (33.3)

32 (38.1)

18 (21.4)

8 (61.5)

0.49

1.00

0.32

Antibiotic treatment stopped after rtPCR, n (%)

2 (5.7)

2 (6.1)

0 (0.0)

2 (2.4)

4 (4.8)

0 (0.0)

1.00

1.00

0.67

Antibiotic treatment started after rtPCR, n (%)

5 (14.3)

4 (12.1)

2 (33.3)

8 (9.5)

7 (8.3)

3 (23.1)

1.00

0.54

0.64

Antibiotic treatment before and after rtPCR, n (%)

18 (51.4)

20 (60.6)

2 (33.3)

42 (50.0)

55 (65.5)

2 (15.4)

0.45

0.71

0.89

Correct management, n (%)

12 (34.3)

24 (72.7)

4 (66.7)

 

62 (73.8)

8 (61.5)

0.002

0.30

n/a

  1. n number; rtPCR, real-time polymerase chain reaction
  2. aCases without detection of bacteria were evaluated as clinically bacterial if they fulfilled one of the following criteria: unilobular or multilobular pulmonary infiltrate or CRP >100 mg/l or PCT >0.25 μg/l or antibiotic therapy before rtPCR and no bacterium detection and biomarkers indeterminate (CRP >100 mg/l and PCT ≤0.25 μg/l or CRP between 51 and 100 mg/l and PCT not available)
  3. bCases with a detected viral pathogen excluding those patients with a clinically bacterial co-infection (as described above)
  4. cMantel-Haenszel chi square test or Fisher exact test were used