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Table 8 Change of antibiotic therapy after rtPCR, adult patients with another indication for antibiotics were excluded

From: Impact of viral multiplex real-time PCR on management of respiratory tract infection: a retrospective cohort study

  Viral Bacterial Mixed No pathogen Clinically Clinically p-value c
(n = 35) (n = 33) (n = 6) (n = 84) bacterial a (n = 84) viral b (n = 13) Viral vs. bacterial Viral vs. mixed Viral vs. no pathogen
No antibiotic treatment before and after rtPCR, n (%) 10 (28.6) 7 (21.2) 2 (33.3) 32 (38.1) 18 (21.4) 8 (61.5) 0.49 1.00 0.32
Antibiotic treatment stopped after rtPCR, n (%) 2 (5.7) 2 (6.1) 0 (0.0) 2 (2.4) 4 (4.8) 0 (0.0) 1.00 1.00 0.67
Antibiotic treatment started after rtPCR, n (%) 5 (14.3) 4 (12.1) 2 (33.3) 8 (9.5) 7 (8.3) 3 (23.1) 1.00 0.54 0.64
Antibiotic treatment before and after rtPCR, n (%) 18 (51.4) 20 (60.6) 2 (33.3) 42 (50.0) 55 (65.5) 2 (15.4) 0.45 0.71 0.89
Correct management, n (%) 12 (34.3) 24 (72.7) 4 (66.7)   62 (73.8) 8 (61.5) 0.002 0.30 n/a
  1. n number; rtPCR, real-time polymerase chain reaction
  2. aCases without detection of bacteria were evaluated as clinically bacterial if they fulfilled one of the following criteria: unilobular or multilobular pulmonary infiltrate or CRP >100 mg/l or PCT >0.25 μg/l or antibiotic therapy before rtPCR and no bacterium detection and biomarkers indeterminate (CRP >100 mg/l and PCT ≤0.25 μg/l or CRP between 51 and 100 mg/l and PCT not available)
  3. bCases with a detected viral pathogen excluding those patients with a clinically bacterial co-infection (as described above)
  4. cMantel-Haenszel chi square test or Fisher exact test were used