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Table 9 Change of antibiotic therapy after rtPCR, pediatric patients with another indication for antibiotics were excluded

From: Impact of viral multiplex real-time PCR on management of respiratory tract infection: a retrospective cohort study

  Viral Bacterial Mixed No pathogen Clinically Clinically p-value c
(n = 27) (n = 4) (n = 3) (n = 18) bacterial a (n = 22) viral b (n = 15) Viral vs. bacterial Viral vs. mixed Viral vs. no pathogen
No antibiotic treatment before and after rtPCR, n (%) 12 (44.4) 1 (25.0) 0 (0.0) 6 (33.3) 6 (27.3) 11 (73.3) 0.87 0.40 0.46
Antibiotic treatment stopped after rtPCR, n (%) 6 (22.2) 0 (0.0) 0 (0.0) 1 (5.6) 2 (9.1) 4 (26.7) 0.80 1.00 0.27
Antibiotic treatment started after rtPCR, n (%) 1 (3.7) 0 (0.0) 1 (33.3) 3 (16.7) 3 (13.6) 0 (0.0) 1.00 0.39 0.34
Antibiotic treatment before and after rtPCR, n (%) 8 (29.6) 3 (75.0) 2 (66.7) 8 (44.4) 11 (50.0) 0 (0.0) 0.23 0.50 0.32
Correct management, n (%) 18 (66.7) 3 (75.0) 3 (100.0)   14 (63.6) 15 (100.0) 1.00 0.66 n/a
  1. n number; rtPCR, real-time polymerase chain reaction
  2. aCases without detection of bacteria were evaluated as clinically bacterial if they fulfilled one of the following criteria: unilobular or multilobular pulmonary infiltrate or CRP >100 mg/l or PCT >0.25 μg/l or antibiotic therapy before rtPCR and no bacterium detection and biomarkers indeterminate (CRP >100 mg/l and PCT ≤0.25 μg/l or CRP between 51 and 100 mg/l and PCT not available)
  3. bCases with a detected viral pathogen excluding those patients with a clinically bacterial co-infection (as described above)
  4. cMantel-Haenszel chi square test or Fisher exact test were used