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Table 2 Sensitivity and specificity of endorsed molecular assays for rapid detection of drug-resistant TB

From: Rapid molecular assays for detection of tuberculosis

Assay

Detection of drug resistance

Sensitivity %

(95% confidence interval)

Specificity %

(95% confidence interval)

References

Xpert MTB/RIF

RIF

95 (90–97)

98 (97–99)

44*

Xpert Ultra

RIF

92.7 (80.1–98.5)

98 (92.8–99.9)

58*

GenoType MTBDRplus

RIF

Smear positive sample: 88.2 (72.6–96.7)

Smear positive sample: 89.5 (75.2–97.1)

77*

Smear negative and culture positive direct sample: 100 (29.2–100)

Smear negative and culture positive direct sample: 63.6 (30.8–89.1)

INH

Smear positive sample: 91.7 (77.5–98.3)

Smear positive sample: 97.2 (85.5–99.9)

Smear negative and culture positive direct sample: 60 (14.7–94.7)

Smear negative and culture positive direct sample: 100 (66.4–100)

MDR-TB (RMP&INH)

Smear positive sample: 96.4 (81.7–99.9)

Smear positive sample: 100 (88.8–100)

Smear negative and culture positive direct sample: 100 (15.8–100)

Smear negative and culture positive direct sample: 100 (47.8–100)

GenoType MTBDRsl

FLQ

100 (95.8–100)

98.9 (96.1–99.9)

84*

AMK

93.8 (79.2–99.2)

98.5 (95.5–99.7)

KAN

89.2 (79.1–95.6)

98.5 (95.5–99.7)

CPM

86.2 (68.3–96.1)

95.9 (92.2–98.2)

  1. 44*: reference standard was phenotypic culture-based DST
  2. 58*: results were compared with phenotypic susceptibility testing and Xpert MTB/RIF
  3. 77*: results were compared with the conventional liquid culture based reference standard method, BACTEC MGIT 960 culture and DST
  4. 84*: results were compared with phenotypic DST