Malawian children with fast-breathing pneumonia with and without comorbidities

Pneumonia

Table 3 ITIP3 fast-breathing pneumonia cohort and ITIP1 treatment failure rates^a

	ITIP3 fast-breathing pneumonia cohort					ITIP1
	HIV^b,c	Malaria^b,d	Severe acute manlnutrition^b,f	Anemia^b,e	Total	3 days placebo	3 days amoxicillin
	(n = 54)	(n = 17)	(n = 2)	(n = 14)	(n = 73)	(n = 543)	(n = 552)
Treatment failure^g	1 (1.9%)	1 (5.9%)	0 (0.0%)	1 (7.1%)	3 (4.1%)	41 (7.6%)	25 (4.5%)
WHO IMCI general danger^g signs	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3 (0.6%)	5 (0.9%)
Severe respiratory distress^g	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6 (1.1%)	0 (0.0%)
Hypoxemia^g	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)
Chest indrawing^g	1 (1.9%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (1.4%)	15 (2.8%)	10 (1.8%)
Very fast breathing^g	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3 (0.6%)	3 (0.5%)
Fever^g	0 (0.0%)	1 (5.9%)	0 (0.0%)	1 (7.1%)	1 (1.4%)	15 (2.8%)	2 (0.4%)
Death^h	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)
Change in antibiotic^g	1 (1.9%)	1 (5.9%)	0 (0.0%)	1 (7.1%)	3 (4.1%)	37 (6.8%)	21 (3.8%)

^aTreatment failure rates are a percentage of those with a known treatment failure status
^bSubgroup based on data from screening/enrollment; subgroups are not mutually exclusive
^cHIV defined as a positive HIV-1 rapid diagnostic test or HIV-exposed
^dMalaria defined as a positive malaria rapid diagnostic test
^eAnemia defined as a hemoglobin < 8.0 g/dL
^fSevere acute malnutrition defined as MUAC < 115 mm or WFH z-score < −3
^gOn Day 6 for ITIP3; on or prior to Day 4 for ITIP1
^hOn or prior to Day 6 for ITIP3; on or prior to Day 4 for ITIP1

ISSN: 2200-6133