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Table 4 ITIP3 fast-breathing pneumonia cohort and ITIP1 clinical cure ratesa

From: Malawian children with fast-breathing pneumonia with and without comorbidities

  ITIP3 fast-breathing pneumonia cohort ITIP1
HIVb,c Malariab,d Severe acute malnutritionb,f Anemiab,e Total 3 days placebo 3 days amoxicillin
(N = 57) (N = 20) (N = 2) (N = 17) (N = 79) (N = 562) (N = 564)
Day 14 clinical outcome
 Cured 50 / 51 (98%) 15 / 17 (88.2%) 2 / 2 (100%) 13 / 14 (92.9%) 68 / 71 (95.8%) 517 / 527 (98.1%) 525 / 543 (96.7%)
 Not cured 1 / 51 (2%) 2 / 17 (11.8%) 0 / 2 (0%) 1 / 14 (7.1%) 3 / 71 (4.2%) 10 / 527 (1.9%) 18 / 543 (3.3%)
 Unknown clinical outcome 6 / 57 (10.5%) 3 / 20 (15%) 0 / 2 (0%) 3 / 17 (17.6%) 8 / 79 (10.1%) 35 / 562 (6.2%) 21 / 564 (3.7%)
 Loss to follow-up or consent withdrawn 3 / 57 (5.3%) 3 / 20 (15%) 0 / 2 (0%) 3 / 17 (17.6%) 5 / 79 (6.3%) 27 / 562 (4.8%) 18 / 564 (3.2%)
 Missing visit 3 / 57 (5.3%) 0 / 20 (0%) 0 / 2 (0%) 0 / 17 (0%) 3 / 79 (3.8%) 8 / 562 (1.4%) 3 / 564 (0.5%)
  1. aCured and not cured rates are a percentage of those with a known clinical outcome status; unknown rates are a percentage of total
  2. bSubgroup based on data from screening/enrollment; subgroups are not mutually exclusive
  3. cHIV defined as a positive HIV-1 rapid diagnostic test or HIV-exposed
  4. dMalaria defined as a positive malaria rapid diagnostic test
  5. eAnemia defined as a hemoglobin < 8.0 g/dL
  6. fSevere acute malnutrition defined as MUAC < 115 mm or WFH z-score < −3
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