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Table 4 ITIP3 fast-breathing pneumonia cohort and ITIP1 clinical cure ratesa

From: Malawian children with fast-breathing pneumonia with and without comorbidities

 

ITIP3 fast-breathing pneumonia cohort

ITIP1

HIVb,c

Malariab,d

Severe acute malnutritionb,f

Anemiab,e

Total

3 days placebo

3 days amoxicillin

(N = 57)

(N = 20)

(N = 2)

(N = 17)

(N = 79)

(N = 562)

(N = 564)

Day 14 clinical outcome

 Cured

50 / 51 (98%)

15 / 17 (88.2%)

2 / 2 (100%)

13 / 14 (92.9%)

68 / 71 (95.8%)

517 / 527 (98.1%)

525 / 543 (96.7%)

 Not cured

1 / 51 (2%)

2 / 17 (11.8%)

0 / 2 (0%)

1 / 14 (7.1%)

3 / 71 (4.2%)

10 / 527 (1.9%)

18 / 543 (3.3%)

 Unknown clinical outcome

6 / 57 (10.5%)

3 / 20 (15%)

0 / 2 (0%)

3 / 17 (17.6%)

8 / 79 (10.1%)

35 / 562 (6.2%)

21 / 564 (3.7%)

 Loss to follow-up or consent withdrawn

3 / 57 (5.3%)

3 / 20 (15%)

0 / 2 (0%)

3 / 17 (17.6%)

5 / 79 (6.3%)

27 / 562 (4.8%)

18 / 564 (3.2%)

 Missing visit

3 / 57 (5.3%)

0 / 20 (0%)

0 / 2 (0%)

0 / 17 (0%)

3 / 79 (3.8%)

8 / 562 (1.4%)

3 / 564 (0.5%)

  1. aCured and not cured rates are a percentage of those with a known clinical outcome status; unknown rates are a percentage of total
  2. bSubgroup based on data from screening/enrollment; subgroups are not mutually exclusive
  3. cHIV defined as a positive HIV-1 rapid diagnostic test or HIV-exposed
  4. dMalaria defined as a positive malaria rapid diagnostic test
  5. eAnemia defined as a hemoglobin < 8.0 g/dL
  6. fSevere acute malnutrition defined as MUAC < 115 mm or WFH z-score < −3