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Table 1 Patients’ baseline characteristics in before and after propensity score-matched groups

From: Additional effect of azithromycin over β-lactam alone for severe community-acquired pneumonia-associated acute respiratory distress syndrome: a retrospective cohort study

 

Before propensity score-matched groups

 

After propensity score-matched groups

 
 

Azithromycin group

Control group

SMD

Azithromycin group

Control group

SMD

Variable

n = 226

n = 1031

 

n = 139

n = 556

 

Age (years), mean (SD)

70.0 (14.8)

73.6 (12.9)

0.25

71.8 (13.7)

72.7 (12.9)

0.07

Sex (female), n (%)

64 (28.3)

316 (30.6)

0.05

39 (28.1)

161 (29.0)

0.02

Hospital type (academic), n (%)

50 (22.1)

162 (15.7)

0.16

30 (21.6)

99 (17.8)

0.09

Hospital volume (cases/year), mean (SD)

118.0 (58.6)

106.9 (60.8)

0.19

108.9 (48.9)

111.1 (64.7)

0.04

Comorbidities, n (%)

 Myocardial infarction

3 (1.3)

15 (1.5)

0.01

2 (1.4)

3 (0.5)

0.09

 Congestive heart failure

45 (19.9)

239 (23.2)

0.08

33 (23.7)

122 (21.9)

0.04

 Peripheral vascular disease

7 (3.1)

11 (1.1)

0.14

3 (2.2)

9 (1.6)

0.04

 Cerebrovascular disease

9 (4.0)

69 (6.7)

0.12

8 (5.8)

34 (6.1)

0.02

 Dementia

1 (0.4)

25 (2.4)

0.17

1 (0.7)

3 (0.5)

0.02

 Chronic pulmonary disease

18 (8.0)

93 (9.0)

0.04

11 (7.9)

51 (9.2)

0.05

 Peptic ulcer

6 (2.7)

34 (3.3)

0.04

4 (2.9)

15 (2.7)

0.01

 Mild liver disease

7 (3.1)

29 (2.8)

0.02

4 (2.9)

17 (3.1)

0.01

 Diabetes without chronic complications

30 (13.3)

164 (15.9)

0.08

21 (15.1)

82 (14.7)

0.01

 Diabetes with chronic complications

12 (5.3)

48 (4.7)

0.03

8 (5.8)

26 (4.7)

0.05

 Renal disease

12 (5.3)

74 (7.2)

0.08

10 (7.2)

37 (6.7)

0.02

Consciousness level, n (%)

 Alert

136 (60.2)

517 (50.1)

0.20

79 (56.8)

307 (55.2)

0.03

 Delirium

48 (21.2)

232 (22.5)

0.03

32 (23.0)

120 (21.6)

0.04

 Somnolence

11 (4.9)

100 (9.7)

0.19

9 (6.5)

34 (6.1)

0.02

 Coma

26 (11.5)

149 (14.5)

0.09

17 (12.2)

78 (14.0)

0.05

A-DROP category, n (%)

 Mild

1 (0.3)

5 (0.5)

0.01

0 (0.0)

2 (0.4)

0.09

 Moderate

28 (12.4)

83 (8.1)

0.14

14 (10.1)

54 (9.7)

0.01

 Severe

19 (8.4)

86 (8.3)

<  0.01

12 (8.6)

50 (9.0)

0.01

 Extremely severe

25 (11.1)

185 (17.9)

0.20

17 (12.2)

84 (15.1)

0.08

 Missing

154 (68.1)

677 (65.7)

0.05

96 (69.1)

368 (66.2)

0.06

Intervention, n (%)

 Renal replacement therapy

36 (15.9)

102 (9.9)

0.18

15 (10.8)

59 (10.6)

0.01

 Extracorporeal membrane oxygenation

14 (6.2)

9 (0.9)

0.29

1 (0.7)

3 (0.5)

0.02

Catecholamines, n (%)

 Dopamine

55 (24.3)

373 (36.2)

0.26

37 (26.6)

169 (30.4)

0.08

 Noradrenaline

101 (44.7)

344 (33.4)

0.23

52 (37.4)

212 (38.1)

0.02

Transfusion, n (%)

 Red cell transfusion

18 (8.0)

97 (9.4)

0.05

12 (8.6)

40 (7.2)

0.05

 Platelets transfusion

7 (3.1)

34 (3.3)

0.01

1 (0.7)

10 (1.8)

0.09

 Fresh frozen plasma transfusion

4 (1.8)

41 (4.0)

0.13

2 (1.4)

8 (1.4)

<  0.01

Other treatment, n (%)

 Antithrombin

30 (13.3)

92 (8.9)

0.14

12 (8.6)

47 (8.5)

0.01

 Recombinant human soluble thrombomodulin

36 (15.9)

92 (8.9)

0.21

11 (7.9)

58 (10.4)

0.09

 Immunoglobulin

54 (23.9)

238 (23.1)

0.02

36 (25.9)

126 (22.7)

0.08

 Sivelestat sodium

101 (44.7)

532 (51.6)

0.14

68 (48.9)

259 (46.6)

0.05

 Steroid

108 (47.8)

458 (44.4)

0.07

60 (43.2)

251 (45.1)

0.04

Initial antibiotic, n (%)

 Rank 5

110 (48.7)

586 (56.8)

0.16

73 (52.5)

286 (51.4)

0.02

 Rank 4

63 (27.9)

246 (23.9)

0.09

41 (29.5)

149 (26.8)

0.06

 Rank 3

63 (27.9)

164 (15.9)

0.29

27 (19.4)

119 (21.4)

0.05

 Rank 2

27 (11.9)

153 (14.8)

0.09

18 (12.9)

76 (13.7)

0.02

 Rank 1

7 (3.1)

31 (3.0)

0.01

3 (2.2)

12 (2.2)

<  0.01

 Anti-MRSA drug

18 (8.0)

79 (7.7)

0.01

12 (8.6)

36 (6.5)

0.08

 Fluoroquinolone

37 (16.4)

376 (36.5)

0.47

34 (24.5)

121 (21.8)

0.06

  1. Abbreviations: A-DROP severity score consisting of age, dehydration, respiration, orientation, and blood pressure, MRSA methicillin-resistant Staphylococcus aureus, SD standard deviation, SMD standardized mean difference