Table 6 Prominent pneumococcal virulence proteins with vaccine potential
From: The remarkable history of pneumococcal vaccination: an ongoing challenge
Pneumococcal Protein | Virulence activities |
|---|---|
Choline-binding protein A (CbpA) | Adhesin that binds to the polymeric immunoglobulin receptor, the laminin receptor and complement component 3 |
Histidine triad protein D (PhtD) | A factor H (FH)-binding protein that interferes with activation of the alternate complement pathway |
Pneumococcal choline-binding protein A (PcpA) | Adhesin that also suppresses innate immune mechanisms |
Pneumococcal surface adhesin A (PsaA) | Adhesin that also functions as a manganese permease complex |
Pneumococcal surface protein A (PspA) | Adhesin that also inhibits recognition of the pneumococcus by C-reactive protein; also inactivates both factor H (FH) of the alternative complement pathway and lactoferrin |
Pneumolysin | The membrane pore-forming eukaryotic cell cytotoxin of the pneumococcus |