Table 7 Types of putative recombinant pneumococcal protein-based vaccines
From: The remarkable history of pneumococcal vaccination: an ongoing challenge
• Exclusively protein-based, containing detoxified recombinant pneumococcal proteins individually or in combination |
• Fusion/hybrid vaccines alone or packaged in nanoparticles/nanogels |
• PCVs boosted with added recombinant pneumococcal proteins |
• Novel PCVs based on recombinant pneumococcal carrier proteins |
• Inactivated, non-encapsulated whole cell vaccines manipulated to express native, as well as a limited number of recombinant proteins |
• Early phase nucleic acid vaccines (DNA and mRNA) expressing recombinant pneumococcal proteins |