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Table 4 DNA-sensing receptors

From: Innate immune responses in pneumonia

Name

Ligand

Location

Function

Signaling

Ref

cGAS

Cytosolic DNA

Cytoplasm

Production of type I IFN and pro-inflammatory cytokines

STING

[70]

IFI16/IFI204

Intracellular ss and dsDNA

Nucleus

Type I IFN

STING

[71]