Table 5 C-type lectin receptors^a

CLEC4D (MCL)

α-mannans

Cell surface

II – Type 2 receptors

NF-κB

[73]

Surfactant Protein A&D

Respiratory pathogens

Secreted

III—Collectins

Enhancement of phagocytosis & IL4/IL13 repair pathway

[82]

Dectin-1

β-glucan; galectin-9; annexins; vimentin; tropomyosin; N-glycan

Cell membrane

V – NK receptors

Syk-dependent ROS; NFAT and NFκB signaling

[83]

Dectin-2

α-mannans

Cell membrane

II – Type 2 receptors

Syk, PKCδ and CARD9–Bcl10–Malt1

[84]

Versican

CD44, PSGL-1, TLR2; P and L-selectins

Extracellular

I—Proteoglycan

MyD88

[85]

Mincle

Glucosyl-diacylglycerol (Gly-DAG); microbial lipidic species

Cell surface

II – Type 2 receptors

Syk, PKCδ, CARD9–Bcl10–Malt1 and MAPK

[86]