Table 6 Scavenger receptors^a

LOX-1

Oxidized lipoproteins; activated platelets; advanced glycation end products; apoptotic cells; live bacteria

Cell Surface

Class E

NFκB; MAPK; NADPH oxidase

Also a C-type lectin receptor

[106]

MARCO

Bacteria; LPS; LTA; CpG DNA

Cell surface

Class A

Unclear, cooperation with TLRs

[96]

CD36

Long chain fatty acids; PAMPs; DAMPs; proteins containing TSR domains

Cell Surface

Class B

MAPK; PPAR-γ; NF-κB; ROS

[107]

SR-A

HSPs; PAMPs; oxidized LDL; proteoglycans; poly I:C; major vault protein

Cell surface

Class A

PI3K; NF-κB; MAPK

[108]

CD5L

CD36; PAMPs; Live bacteria

Secreted

Class I

Inhibition of apoptosis

Unknown mechanism

[109]

SR-BI

HDL; modified LDL; phospholipids

Cell surface

Class B

eNOS activation; phospholipase C & D; PI3K; MAPK

[110]