Table 1 Main characteristics of randomised controlled trials meeting selection criteria for short duration of antibiotic treatment of non-severe CAP in children
Study (year) [Reference] | Country | Patient’s age | No. of paients | Regimens compared | Case definition | Study results (cure rate) p value |
|---|---|---|---|---|---|---|
Hazir et al. 2007 [7] | Pakistan | 2–59 months | 876 | 3 days amoxicillin (standard dose) vs. 3 days amoxicillin (high dose) | WHOa | 97.0% vs. 95.9% (p = 0.55) |
Agarwal et al. 2004 [8] | India | 2–59 months | 2,188 | 3 days amoxicillin vs. 5 days amoxicillin | WHO | 89.5% vs. 89.9% (p = 0.78) |
Hazir et al. 2011 [9] | Pakistan | 2–59 months | 873 | 3 days amoxicillin vs. placebo | WHO | 92.8% vs. 91.7% (p = 0.60) |
MASCOT 2003 [10] | Pakistan | 2–59 months | 2,000 | 3 days amoxicillin vs. 5 days amoxicillin | WHO | 79% vs. 80% (p = 0.74) |
Awasthi et al. 2008 [23] | India | 2–59 months | 2,009 | 3 days amoxicillin vs. 5 days co-trimoxazole | WHO | 86% vs. 90% (p = 0.24) |
Rasmussen et al. 2005 [24] | Pakistan | 2–59 months | 1,143 | 5 days co-trimoxazole (standard dose) vs. 5 days co-trimoxazole (high dose) | WHO | 80.6% vs. 78.8% (p = 0.46) |
Catchup 2002 [25] | Pakistan | 2–59 months | 1,459 | 5 days amoxicillin vs. 5 days co-trimoxazole | WHO | 83.9% vs. 81.1% (p = 0.17) |
Ferwerda et al. 2001 [22] | The Netherlands | 3 months–12 years | 118 | 3 days azithromycin vs. 10 days co-amoxiclav | CXR or clinical signsb | 91% vs. 87% (p = 0.55) |