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Table 2 Results of studies on viral aetiology in hospitalised adults and older children with acute lower respiratory tract infection or pneumonia in sub-Saharan Africa

From: Viral pneumonia in adults and older children in sub-Saharan Africa — epidemiology, aetiology, diagnosis and management

Study, year [ ] Reference

Patients (n)

HIV-positive (%)

Virology result

   

>1 virus

Influenza virus

Adenovirus

Rhinovirus

PIV1-3

RSV

hMPV

Other

Joosting et al., 1979a [44]

1012

NS

477 (47.1%)

Any: 384 (37.9%)

A: 287 (28.4%)

B: 87 (8.6%)

C: 10(1.0%)

45 (4.4%)

-

17 (1.7%)

8 (0.8%)

-

Enterovirus: 1

Scott et al., 2000b [8]

281

52%

16 (5.7%)

5%

A: 12 (4.3%)

B: 2 (0.7%)

2 (0.7%)

-

-

0

-

 

Hartung et al., 2011c [45]

51

94%

11 (21.6%)

A: 1

1 (9%)

4 (36%)d

PIV1: 1 (9%)

1 (9%)

 

Bocavirus: 1 (9%)

Coronavirus NL63: 1 (9%);

Coronavirus OC43: 1 (9%)

Feikin et al., 2012e [39]

396f

49%

230 (58%)

Any: 37 (9%)

A: 29 (7%)

B: 8 (2%)

29 (7%)

39 (35%)h

PIV1: 2 (0.5%)

PIV2: 6 (2.0%)

PIV3: 14(4.0%)

33 (8%)

10 (3%)

 

Pretorius et al., 2012i [41]

4006g

NS

5–24 years: 51%

25–44 years: 33.8%

45–64 years: 28.7%

>65 years: 24.2%

Any: 343 (8.6%)

A(H3N2): 102 (2.5%)

A(H1N1): 104 (2.6%)

B: 137 (3.4%)

251 (6.3%)

653 (16%)

Any: 145 (3.4%)

PIV1: 12 (0.3%)

PIV2: 27 (0.7%)

PIV3: 96 (2.4%)

134 (3.3%)

62 (1.5%)

Enterovirus: 63 (1.6%)

  1. HIV, human immunodeficiency virus; NS, not stated; PIV1-3, parainfluenza virus type 1 to 3; RSV, respiratory syncytial virus; hMPV, human metapneumovirus.
  2. aTested for Influenza A, B & C viruses, PIV1-3, RSV, adenovirus, herpesvirus, and enterovirus.
  3. bTested for Influenza A & B viruses, adenovirus, and RSV.
  4. cTested for Influenza A & B viruses, PIV1-4, adenovirus, rhinovirus, RSV type A & B, hMPV; Coronavirus 229E & OC43, human Coronavirus NL63, bocavirus.
  5. d2 were co-infected with Pneumocystis jiroveci pneumonia; 1 with pulmonary Mycobacterium tuberculosis; 1 with pulmonary Kaposi’s sarcoma.
  6. eTested for Influenza A & B viruses, PIV1-3, adenovirus, RSV, and hMPV (also rhinovirus, enterovirus and parechovirus from January 2009).
  7. fOnly included hospitalised patients aged >5 years in whom naso/oropharngeal specimens taken.
  8. gOnly included patients aged >5 years.
  9. hInclude enterovirus due to cross-reactivity on real-time transcriptase polymerase chain reaction (RT-PCR).
  10. iTested for Influenza A & B viruses, PIV1-3, adenovirus, RSV, hMPV, rhinovirus and enterovirus.