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Table 3 An example of the loss of discriminating power in cohorts with different characteristics

From: Pneumonia severity scores in resource poor settings

 

Severity Scores

 

CRB-65 = 0

CRB-65 ≥2

CRB-65 ≥3

 

Germany

Malawi

Germany

Malawi

Germany

Malawi

True Positive

0

0

50

16

13

3

False Positive

0

0

366

38

53

4

True Negative

375

60

1,034

158

1,347

192

False Negative

0

4

27

28

64

41

PPV (%)

N/A

N/A

12

30

19

43

NPV (%)

50

94

97

85

95

82

Sensitivity (%)

0

0

65

36

17

7

Specificity (%)

100

1

74

81

96

98

  1. Note: CRB-65 scores have been applied to patients from Germany [23] and from Malawi [5]. Numbers indicate the number of patients in each category.
  2. NPV, negative predictive value; PPV, positive predictive value; N/A, incalculable