• Anti-platelet agents |  |
 o inhibitors of production of thromboxane A2 |  |
 o antagonists of thromboxane A2 receptors |  |
 o antagonists of ADP-activated P2Y12 receptors |  |
 o antagonists of thrombin-activated proteinase-activated receptor 1 |  |
 o GPIIb/IIIa inhibitors |  |
• Agents targeting pneumolysin |  |
 o macrolides |  |
 o statins |  |
 o cholesterol-rich liposomes |  |
• Immunisation |  |
 o PCV 13 with or without immunogenic pneumolysoid |  |