Global burden of childhood tuberculosis

Pneumonia

Table 1 Annual estimates of the childhood tuberculosis (TB) burden among children aged 0-14 years

Measure	TB disease	Fraction of all pediatric TB cases	Latent TB infection
TB incidence	999,792 (95% CI: 937,877 – 1,055,414)^a
	847,000 (IQR: 558,000 – 1,280,000)^b	N/A	67 million (IQR: 52.3 million – 85.7 million)^b
	1,000,000 (UI: 900,000–1,100,000)^c
	150,000^d
INH-R TB	120,872 (95% CI: 96,628–149,059)^c	12.1% (95% CI: 9.8%–14.8%)^c
INH-R TB	84,000^be	9.9%^b	6.8 million^b
MDR-TB	31,948 (95% CI: 25,594–38,663)^a	3.2%^a
MDR-TB	24,800 (IQR: 16,100–37,400)^b	2.9% (IQR: 2.7%–3.1%)^b	2.0 million (IQR: 1.6 million–2.6 million)^b
Mortality	136,000 (range: 115,000–157,000)^c	13.6%^c	N/A
Mortality	60,000^d

INH-R Isoniazid resistant, MDR Multidrug-resistant, CI Confidence Interval, IQR Interquartile range, UI Uncertainty Interval
^aJenkins et al. 2014 [17]; ^bDodd et al. 2016 [21]; ^cWHO 2015 [2]; ^dMurray et al. 2014 (Note: there are no uncertainty ranges around these estimates); Yuen et al. 2015 [35]
^eNote that Dodd et al. 2016 produced an estimate of INH-R TB mono-resistance of 58,300 (IQR: 38,300 – 87,000) cases. The figure presented of 84,000 represents all forms of INH-R (i.e. mono-resistance plus MDR-TB) but because this was not formally estimated in Dodd et al. 2016, there is no IQR around this result

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