Non-adherence to community oral-antibiotic treatment in children with fast-breathing pneumonia in Malawi– secondary analysis of a prospective cohort study

Table 2 Multivariable regression for clinical and diagnostic factors associated with non- adherence

	Adherence measured at 80%			Adherence measured at 100%
Variable	Odds Ratio	P Value	CI	Odds ratio	P Value	CI
Any Concurrent Diagnosis^a	1.75	0.050	1.00–3.07	1.81	0.004	1.21–2.71
Prescribed multiple drugs^b	1.57	0.159	0.84–2.96	1.09	0.711	0.70–1.68
Duration of illness > 24 h	2.14	0.004	1.27–3.58	1.88	0.001	1.29–2.73
Abnormal oxygen saturation^c	0.82	0.606	0.39–1.73	1.44	0.148	0.88–2.36
Very fast breathing^d	0.82	0.754	0.22–2.92	0.66	0.355	0.27–1.60
Abnormal heart rate^e	0.80	0.419	0.41–1.45	1.41	0.123	0.91–2.17
Fever^f	1.50	0.150	0.86–2.60	1.06	0.777	0.70–1.61
Vomited antibiotics	0.82	0.605	0.38–1.77	0.85	0.574	0.48–1.50
Age (12–23months)	0.68	0.206	0.38–1.23	1.05	0.822	0.67–1.65
Age (24–56 month)	0.41	0.007	0.21–0.78	0.68	0.111	0.43–1.09
Sex (Male)	0.91	0.740	0.54–1.51	1.06	0.750	0.73–1.54
Pseudo R2 = 0.061				Pseudo R2 = 0.045

^aDiagnoses included: malaria, diarrhoea, ear infection, rash and other specified
^bDrugs included: Paracetamol, Lumefantrine Artemether (LA) and others specified (including aspirin, topical creams, oral salbutamol)
^cNormal: = > 95%; Abnormal: <= 94%
^dFast breathing (breaths per minute): 40–59 (age 12–59 months) 50–69 (age 2–11 months); Very fast breathing: > = 60 (age 12–59 months) > =70 (age 2–11 months)
^eNormal (beat per minute): <159 (age 2-11months), <149 (age 12–23 months), <139 (age 24–59 months); Abnormal: > = 159 (age 2-11months), > = 149 (age 12–23 months), > = 139 (age 24–59 months)
^fNormal: <=37.4 °C; Fever: > 37.4 °C

ISSN: 2200-6133