Table 2 Types and applications of meningococcal vaccines

Purified capsular polysaccharide-based vaccines (not available for serogroup B)

i) Serogroups A,C (bivalent)

ii) Serogroups A,C, W-135 (trivalent)

iii) Serogroups A,C,Y,W-135 (tetravalent)

Weakly immunogenic; recommended for high-risk persons aged ≥2 years

[133]

Tetravalent capsular polysaccharide conjugate vaccines. Two types available: Menactra® and Menveo®

Serogroups A,C,Y,W-135 covered by both vaccines

Improved immunogenicity; suitable for immunization of young children; prevent nasopharyngeal carriage; induce herd protection

[134]

Protein-based, capsular polysaccharide-free vaccines targeting serogroup B. Two types available: Trumenba® and Bexsero®

i) Two recombinant variants of serogroup B fHbp (Trumenba®)

ii) Three recombinant serogroup B proteins (fHbp; NHBA; NadA)* and vesicle-packaged Porin A (Bexero®)

High-risk persons aged ≥10–25 years

High-risk persons aged ≥10–25 years and young children

[134,135,136,137,138,139,140]