Table 2 ACP episode IRs and 95% CIs by setting and study period for commercially insured children, in episodes per 100,000 PY, and percent change from prior period (1998–2018)

All ages

Ages < 2

Period

Overall

Outpatient

Inpatient

Overall

Outpatient

Inpatient

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

Pre-PCV7

2,074

(2,051; 2,097)

–

1,864

(1,842; 1,885)

–

211

(203; 218)

–

5,322

(5,197; 5,450)

–

4,302

(4,190; 4,417)

–

1,020

(967; 1,077)

–

Early PCV7

2,006

(1,999; 2,013)

-3.3%

1,825

(1,819; 1,832)

-2.1%

181

(179; 183)

-13.8%

4,788

(4,754; 4,823)

-10.0%

3,975

(3,944; 4,007)

-7.6%

813

(799; 828)

-20.3%

Late PCV7

2,213

(2,208; 2,219)

10.3%

2,034

(2,029; 2,039)

11.5%

179

(178; 181)

-1.1%

4,668

(4,642; 4,693)

-2.5%

3,953

(3,929; 3,977)

-0.6%

715

(705; 725)

-12.1%

Early PCV13

2,238

(2,232; 2,243)

1.1%

2,103

(2,098; 2,109)

3.4%

134

(133; 136)

-25.1%

4,232

(4,208; 4,257)

-9.3%

3,700

(3,677; 3,723)

-6.4%

533

(524; 541)

-25.5%

Late PCV13

1,986

(1,981; 1,991)

-11.3%

1,888

(1,883; 1,893)

-10.2%

98

(97; 99)

-26.9%

3,471

(3,449; 3,492)

-18.0%

3,104

(3,083; 3,124)

-16.1%

367

(360; 374)

-31.1%

Ages 2–4

Ages 5–17

Overall

Outpatient

Inpatient

Overall

Outpatient

Inpatient

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

IR

(95% CI)

%Δ from prior period

Pre-PCV7

4,012

(3,927; 4,099)

–

3,652

(3,571; 3,734)

–

361

(336; 387)

–

1,383

(1,362; 1,404)

–

1,287

(1,267; 1,307)

–

96

(91; 102)

–

Early PCV7

3,870

(3,846; 3,894)

-3.5%

3,549

(3,526; 3,572)

-2.8%

321

(314; 328)

-11.1%

1,334

(1,328; 1,340)

-3.5%

1,252

(1,246; 1,258)

-2.7%

82

(80; 83)

-14.6%

Late PCV7

4,152

(4,133; 4,171)

7.3%

3,841

(3,823; 3,859)

8.2%

311

(306; 316)

-3.1%

1,546

(1,541; 1,551)

15.9%

1,455

(1,450; 1,460)

16.2%

90

(89; 92)

11.0%

Early PCV13

4,246

(4,227; 4,265)

2.3%

4,007

(3,989; 4,026)

4.3%

239

(234; 243)

-23.2%

1,624

(1,619; 1,629)

5.0%

1,555

(1,550; 1,560)

6.9%

69

(68; 70)

-24.2%

Late PCV13

3,794

(3,776; 3,812)

-10.6%

3,614

(3,596; 3,631)

-9.8%

180

(176; 184)

-24.7%

1,475

(1,470; 1,480)

-9.2%

1,423

(1,419; 1,428)

-8.5%

51

(50; 52)

-26.1%