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Table 2 General characteristics of 124 patients with community-acquired pneumonia (CAP) and comparison between pneumococcal community-acquired pneumonia (P-CAP) episodes and non P-CAP episodes

From: Host genetic variants associated with susceptibility and severity of pneumococcal pneumonia in adult patients

Variable

CAP

N = 124, N (%)

P-CAP

N = 57, N (%)

Non P-CAP

N = 67, N (%)

p

Demographic data

 Age (years)*

70.5 (57–81)

68 (53.5–79)

74 (57–83)

0.15

 Gender, male

78 (62.9)

39 (68.4)

39 (58.2)

0.24

 Current smoker

31 (25)

16 (28.1)

15 (22.4)

0.47

 Former smoker

45 (36.3)

22 (38.6)

23 (34.3)

0.62

 Alcohol abuse

17 (13.7)

7 (12.3)

10 (14.9)

0.67

 BMI, mean (SD)

26.6 (4.76)

25.6 (4.6)

27.1 (4.8)

0.09

 Influenza vaccine

50 (40.3)

22 (38.6)

28 (41.8)

0.72

 Pneumococcal vaccine

17 (13.7)

7 (12.3)

10 (14.9)

0.67

Comorbid conditions

 Charlson score*

1 (0–2)

1 (0–2.5)

1 (0–2)

0.66

 Immunosuppression 1

5 (4)

3 (5.26)

2 (2.99)

0.66

 Prior antibiotic treatment 2

19 (15.3)

6 (10.5)

13 (19.4)

0.17

 Pre-hospital antibiotic treatment 3

18 (14.5)

8 (14)

10 (14.9)

0.89

Clinical features on presentation

 Time from symptom onset to ED visit (hours)*

72 (48–120)

48 (24–96)

72 (48–144)

0.01

 Fever (≥ 38 °C)

51 (41.1)

28 (50.9)

23 (34.3)

0.1

 Dyspnoea

90 (72.6)

39 (68.4)

51 (76.1)

0.34

 Tachypnea (≥ 20 rpm)

87 (78.4)

44 (83)

43 (74.1)

0.26

 Cough

109 (87.9)

52 (91.2)

57 (85.1)

0.3

 Purulent sputum

55 (44.4)

22 (38.6)

33 (49.3)

0.23

 Pleuritical chest pain

43 (34.7)

28 (49.1)

15 (22.4)

0.002

 Septic shock

20 (16.3)

12 (21.1)

8 (12.2)

0.18

 Respiratory failure

73 (59.4)

32 (56.1)

41 (62.1)

0.5

 Severe CAP 4

23 (18.5)

12 (21.1)

11 (16.4)

0.68

 PSI classes*

3 (2–4)

4 (3–4)

3 (2–4)

0.42

 CURB-65 score*

1 (1–2)

2 (1–2)

1 (1–2)

0.29

 Co-infection

39 (31.5)

29 (50.9)

10 (14,9)

< 0.001

Evolution and Outcome

 Time to clinical stability (days)*

2 (1–4)

2 (1–4)

2 (1–3.5)

0.33

 ICU admission

11 (8.87)

4 (7.02)

7 (10.5)

0.51

 Need for mechanical ventilation

6 (5.84)

1 (1.75)

5 (7.46)

0.28

 Length of hospital stay (days)*

6 (3–10)

6 (4.5–9)

6 (2–10)

0.78

 In-hospital mortality

1 (0.81)

0

1 (1.49)

1

  1. 1Immunosuppression: chronic corticosteroid therapy, severe neutropenia, solid or hematopoietic organ transplantation, acquired immunodeficiency syndrome and use of chemotherapy, immunosuppressive agents or biological drugs
  2. 2Prior antibiotic treatment: intake of antibiotic 3 months before hospitalization
  3. 3Pre-hospital antibiotic treatment: oral intake of antibiotic > 24 hours prior to hospitalization for the same episode of acute disease
  4. 4 Severe CAP: presence of septic shock, need of mechanical ventilation or Intensive Care Unit admission
  5. IQR interquartile range, SD standard deviation, ICU Intensive Care Unit
  6. * median (IQR)