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Table 4 Summary of significant polymorphisms associated with severity and outcome of P-CAP

From: Host genetic variants associated with susceptibility and severity of pneumococcal pneumonia in adult patients

Gene

Polymorphism

Reference Allele

Severe CAP

Respiratory failure

CURB-65

PSI

Time to clinical stability

OR (CI 95%)

p

OR (95% CI)

p

Beta (SE)

p

Beta (SE)

p

Beta (SE)

p

IL10

rs3024498

G

1.05 (0.49–2.25)

0.91

0.8 (0.41–1.53)

0.5

0.02 (0.15)

0.91

−0.11 (0.16)

0.51

0.26 (0.45)

0.57

IL10

rs3024509

C

0.17 (0.02–1.39)

0.10

0.18 (0.-0.57)

0.003

−.4 (0.19)

0.04

−.54 (0.21)

0.01

−1 (0.58)

0.09

IL12B

rs730691

T

0.55 (0.27–1.12)

0.10

0.8 (0.46–1.4)

0.43

−.23 (0.13)

0.07

−.28 (0,13)

0.04

−.21 (0.38)

0.59

IL4

rs2227284

A

2.17 (1.02–4.61)

0.04

0.96 (0.52–1.76)

0.89

−.01 (0.14)

0.92

−.07 (0.15)

0.65

−0.02 (0.43)

0.97

ILR1

rs13020778

C

0.84 (0.42–1.67)

0.62

0.64 (0.36–1.14)

0.13

0.06 (0.13)

0.65

0.01 (0.14)

0.94

−0.83 (0.37)

0.03

ILR1

rs2160227

A

0.99 (0.48–2.05)

0.97

0.72 (0.38–1.34)

0.30

0.01 (0.14)

0.93

<.01 (0.15)

1

−1.00 (0.42)

0.02

ILR1

rs3917254

A

0.62 (0.22–1.79)

0.38

0.91 (0.41–2.03)

0.82

−.16 (0.19)

0.40

−.33 (0.2)

0.09

−0.13 (0.55)

0.81

ILR1

rs3917267

A

1.86 (0.9–3.82)

0.09

3.33 (1.62–6.86)

0.001*

0.18 (0.13)

0.19

0.09 (0.14)

0.55

1.07(0.4)

0.008

NFKBIA

rs1050851

A

1.85 (0.9–3.79)

0.09

1.14 (0.58–2.23)

0.71

0.11 (0.14)

0.45

−.10 (0.16)

0.52

−0.19 (0.43)

0.67

NFKBIA

rs696

A

0.88 (0.44–1.78)

0.73

1.55 (0.86–2.8)

0.14

−0.02 (0.13)

0.88

0.15 (0.14)

0.28

0.18 (0.4)

0.65

NFKBIE

rs2282151

C

0.57 (0.24–1.36)

0.21

0.89 (0.47–1.8)

0.71

−.12 (0.15)

0.41

−.12 (0.16)

0.44

0.38 (0.44)

0.39

NFKBIE

rs730775

G

0.79 (0.41–1.53)

0.49

0.75 (0.43–1.29)

0.29

.03 (0.13)

0.84

0 (0.14)

0.99

−0.89 (0.37)

0.02

NFKBIZ

rs11718446

A

1.64 (o.74–3.62)

0.22

0.75 (0.38–1.49)

0.41

0.07 (0.15)

0.64

−.11 (0.17)

0.51

0.08 (0.46)

0.87

NKFBIZ

rs645781

C

0.59 (0.26–1.31)

0.19

0.77 (0.43–1.41)

0.40

−.05 (0.14)

0.74

−.01 (0.15)

0.94

−0.61 (0.41)

0.14

NFKBIZ

rs677011

G

0.79 (0.39–1.6)

0.52

0.82 (0.47–1.43)

0.48

−.11 (0.13)

0.39

0.02 (0.14)

0.89

−0.75 (0.39)

0.06

NFKBIZ

rs9841857

T

1.12 (0.52–2.39)

0.78

1.24 (0.66–2.34)

0.51

0.19 (0.15)

0.19

0.10 (0.16)

0.54

−0.11 (0.44)

0.8

  1. OR Odds ratio, CI confidence interval, Beta beta coefficient, SE Standard error
  2. *Adjusted (Bonferroni corrected) p value = 0.02
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